Proyectos

Actualmente desarrollamos un proyecto FONDECYT Regular Nºº1210583 titulado "Supramolecular activatable photosensitizers for singlet oxygen generation using cucurbiturils and related acyclic containers: understanding the mechanism and their application in photodynamic therapy" el cual está enfocado al estudio de diversas moléculas fotoactivas y su potencial uso en terapia fotodinámica.

Además realizamos I+D mediante un proyecto COPEC UC titulado "Biofungicidas fotoactivos para su uso cítricos y uva de mesa postcosecha" en el cual desarrollamos y probamos nuevos biofungicidas con tecnología fotoactiva para el control de botritis cinerea y penicillium digitatum en frutos.

Publicaciones

(22) J. Robinson-Duggon, N. Mariño-Ocampo, P. Barrias, D. Zúniga-Núñez, G. Günther, A. M. Edwards, A. Greer and D. Fuentealba, 2019. Mechanism of Visible-light Photooxidative Demethylation of Toluidine Blue O. J. Phys. Chem. A, accepted.

 

(21) G. Villarroel-Lecourt, J. Carrasco-Carvajal, F. Andrade-Villalobos, F. Solís-Egaña, I. Merino-San Martín, J. Robinson-Duggon, and D. Fuentealba, 2018. Encapsulation of Chemotherapeutic Drug Melphalan in Cucurbit[7]uril: Effects on Its Alkylating Activity, Hydrolysis, and Cytotoxicity. ACS Omega, 3, 8337-8343.

 

(20) J. Robinson-Duggon, F. Pérez-Mora, L. Dibona-Villanueva, D. Fuentealba, 2018. Potential Applications of Cucurbit[n]urils Inclusion Complexes in Photodynamic Therapy. Isr. J. Chem., 58, 199-214.

 

(19) J. Robinson-Duggon, F. Pérez-Mora, L. Valverde-Vásquez, D. Cortés-Arriagada, J. R. de la Fuente, G. Gunther, D. Fuentealba, 2017. Supramolecular Reversible On-Off switch for Singlet Oxygen Using Cucurbit[n]uril Inclusion Complexes. J. Phys. Chem. C, 121, 21782-21789.

 

(18) C. Espinosa-Bustos, D. Cortés-Arriagada, M. A. Soto-Arriaza, J. Robinson-Duggon, N. Pizarro, A. R. Cabrera, D. Fuentealba, C. O. Salas, 2017. Fluorescence properties of aurone derivatives:an experimental and theoretical study with some preliminary biological applications. Photochem. Photobiol. Sci. 16, 1268-1276.

 

(17) J. Cáceres, J. Robinson-Duggon, A. Tapia, C. Paiva, M. Gómez, C. Bohne, D. Fuentealba, 2017. Photochemical behavior of biosupramolecular assemblies of photosensitizers, cucurbit[n]urils and albumins. Phys. Chem. Chem. Phys., 19, 2574-2582.

 

(16) I. A. Jessop, M. Bustos, D. Hidalgo, C. A. Terraza, A. Tundidor-Camba, M. A. Pardo, D. Fuentealba, M. Hssein, J. C. Bernede, 2016. Synthesis of 2H-benzotriazole based donor-acceptor polymers bearing carbazole derivative as pendant groups: Optical, electronical and photovoltaic properties. Int. J. Electrochem. Sci., 11, 9822-9838.

 

(15) G. Fukuhara, Mami Imai, Denis Fuentealba, Yuki Ishida, Hiroki Kurohara, Cheng Yang, Tadashi Mori, Hiroshi Uyama, Cornelia Bohne, Yoshihisa Inoue, 2016. Electrostatically promoted dynamic hybridization of glucans with cationic polythiophene. Org. Biomol. Chem., 14, 9741-9750. Front Cover

 

(14) D. Fuentealba, C. Venegas, M. Morales and O. Waissbluth, 2016. Comparing photo-Fenton degradation of malachite green using Fe II and Fe III salts under UVA light irradiation. J. Braz. Chem. Soc., 27, 341-348.

 

 

 

 

 

 

 

 

 

(13) M. E. Aliaga, L. García-Río, M. Pessêgo, R. Montecinos, D. Fuentealba, I. Uribe, M. Martín-Pastor, O. García-Beltrán, 2015. Host-guest interaction of coumarin-derivative dyes and cucurbit[7]uril: leading to the formation of supramolecular ternary complexes with mercuric ions. New J. Chem., 39, 3084-3092. 

 

 

 

 

 

 

 

 

 

(12) K. Scholtbach, I. Venegas, C. Bohne, D. Fuentealba, 2015. Time-resolved fluorescence anisotropy as a tool to study guest-cucurbit[n]uril-protein ternary supramolecular interactions. Photochem. Photobiol. Sci., 14 (4), 842-856.

 

 

 

 

 

 

 

 

(11) D. Fuentealba, J. J. López, M. Palominos, C. O. Salas and M. A. Soto-Arriaza, 2015. Gramicidin conformational changes during riboflavin photosensitized oxidation in solution and the effect of N-methylation of tryptophan residues. Photochem. Photobiol. Sci., 14 (4), 748-756.

 

 

 

 

 

 

 

(10) T. Fuenzalida, D. Fuentealba, 2015. A study of the Fenton-mediated oxidation of methylene blue–cucurbit[n]uril complexes. Photochem. Photobiol. Sci., 14 (4), 286-292.

 

 

 

 

 

 

 

(9) D. Fuentealba, H. Kato, M. Nishijima, G. Fukuhara, T. Mori, Y. Inoue, C. Bohne, 2013. Explaining the Highly Enantiomeric Photocyclodimerization of 2-Anthracenecarboxylate Bound to Human Serum Albumin using Time-resolved Anisotropy Studies. J. Am. Chem. Soc., 135 (1), 203-209.

 

 

 

 

 

 

 

(8) A. Bergen, C. Bohne, D. Fuentealba, H. Ihmels, J. W. Bats, H.-J. Deiseroth, E. Neumann, 2012. Studies of the Solvatochromic Emission Properties of N-Aroylurea Derivatives II: Influence of Hydrogen-Bonding Interactions. Photochem. Photobiol. Sci., 11 (12), 1914-1928.

 

 

 

 

 

 

 

 

 

 

 

(7) F. Le Dévédec, D. Fuentealba, S. Strandman, C. Bohne and X. X. Zhu, 2012. Aggregation behavior of pegylated bile acid derivatives. Langmuir, 28 (37), 13431-13440.

 

 

 

 

 

 

 

 

 

(6) A. Bergen, C. Bohne, D. Fuentealba, H. Ihmels, T. C. S. Pace, M. Waidelich, C. Yihwa   and J. W. Bats, 2012. Studies of the Solvatochromic Emission Properties of N-Aroylurea Derivatives I: Influence of the Substitution Pattern. Photochem. Photobiol. Sci., 11 (4), 752-767.

 

 

 

 

 

 

 

 

 

(5) H. Tang, D. Fuentealba, H. Y. Ko, N. Selvapalam, K. Kim and C. Bohne, 2011. Guest Binding Dynamics with Cucurbit[7]uril in the Presence of Cations. J. Am. Chem. Soc., 133 (50), 20623-20633.

 

 

 

 

 

 

 

 

(4) D. Fuentealba, K. Thurber, E. Bovero, T. C. S. Pace and C. Bohne, 2011. Effect of Sodium Chloride on the Binding of Polyaromatic Hydrocarbon Guests with Sodium Cholate Aggregates. Photochem. Photobiol Sci., 10 (9), 1420-1430.

 

(3) D. Fuentealba, B. Friguet and E. Silva, 2009. Advanced Glycation Endproducts induce Photo-crosslinking and Oxidation of Bovine Lens Proteins through Type I Mechanism. Photochem. Photobiol. 85 (1), 185-194.

 

 

(2) F. Ávila, A. Matus, D. Fuentealba, E. Lissi, B. Friguet and E. Silva, 2008. Autosensitized Oxidation of Glycated Bovine Lens Proteins Irradiated with UVA-visible Light at Low Oxygen Concentration. Photochem. Photobiol. Sci., 7 (6), 718-724. Front Cover

 

(1) D. Fuentealba, M. Gálvez, E. Alarcón, E. Lissi and E. Silva, 2007. Photosentizing Activity of Advanced Glycation Endproducts on Tryptophan, Glucose 6-phosphate Dehydrogenase, Human Serum Albumin and Ascorbic Acid Evaluated at Low Oxygen Pressure. Photochem. Photobiol., 83 (3), 563-569.